2019 UC MEXUS-CONACYT Collaborative Research Grant Awards

The 2019 UC MEXUS-CONACYT Collaborative Research Grants competition provided grant awards to 40 projects by co-Principal Investigators from the UC system and Mexican partner institutions. Names of PIs, institutional affiliations, and project titles are listed below.

 

Farooq Azam, Marine Biology Research Division - Scripps Institution of Oceanography, UC San Diego

Laura Gómez-Consarnau, Ocenografía Biológica, CICESE

Understanding Marine Microbial Ecology Using Bacterial Cultures as Models: Study Case in the Upwelling Regions of the Southern California Bight / Estudio de la Ecología Microbiana Marina Utilizando Cultivos Bacterianos como Modelos: Caso Experimental en Zonas de Surgencia de la Cuenca Oceanográfica del Sur de California

Roya Bahreini, Environmental Sciences, UC Riverside

Dara Salcedo González, UMDI-Juriquilla Facultad de Ciencias, UNAM

Molecular Characterization of Organic Aerosols in the Regional Mixed Layer of the Mexico City Metropolitan Area Using Extractive Electrospray Ionization Mass Spectrometry / Caracterización Molecular del Aerosol Orgánico en la Capa de Mezcla Regional de la Zona Metropolitana de la Ciudad de México, Usando Espectrometría de Masas con Ionización por Electrospray Extractivo

Jessica Blois, Life and Environmental Sciences, UC Merced

Joaquín Arroyo-Cabrales, Subdirección de Laboratorios y Apoyo Académico, Instituto Nacional de Antropología e Historia

Range Shifts and Novel Communities: Catalyzing Global Change Research by Integrating Paleodata Across North and Central America / Cambios de Distribución y Comunidades Nuevas: Catalizando la Investigación del Cambio Global Integrando los Paleodatos a lo Largo de Norte y Centroamérica

Ricardo Castro, Materials Science and Engineering, UC Davis

José de Jesús Ku-Herrera and Gustavo Soria-Arguello, Síntesis de Polímeros, CONACYT-Centro de Investigación en Química Aplicada

Light and Resilient Blades for Vertical-Axis Wind Energy Turbines / Álabes Ligeros y Resilientes para Generación de Energía Eólica por Turbinas Verticales

Sean Cutler, Department of Botany and Plant Sciences, UC Riverside

Mario Serrano, Center for Genomic Sciences, UNAM

Characterization of Reactive Oxygen Species-Signaling Pathway by Chemical Genomics / Caracterización por medio de Genómica Química de la Ruta de Señalización Dependiente de Especies Reactivas de Oxígeno

Wolfgang Dillmann, Medicine, UC San Diego

Julieta Anabell Díaz Juárez, Farmacología, Instituto Nacional de Cardiología

Therapeutic Use of Macrophage-Derived Exosomes in Diabetic Cardiac Disease / Uso Terapéutico de Exosomas Derivados de Macrófagos en la Miocardiopatía Diabética

David FitzGerald, Center for Comparative Immigration Studies, UC San Diego

Rafael Guadalupe Alarcón Acosta, Departamento de Estudios Sociales, El Colegio de la Frontera Norte

Children of Mexican Parents Deported from the United States: Policy, Administrative Process and Family Experiences / Hijos de Padres Mexicanos Deportados de Estados Unidos: Políticas Públicas, Proceso Administrativo y Experiencias Familiares

William Gelbart, Chemistry & Biochemistry, UC Los Angeles

Armando Hernández García, Instituto de Química - Química de Biomacromoléculas, UNAM

Engineering Artificial Viral Coat Proteins as a Platform for Directed Evolution / Ingeniería de Proteínas Artificiales de Recubrimiento tipo Virus como Plataforma para Evolución Dirigida

Olivia Graeve, Mechanical and Aerospace Engineering, UC San Diego

Manuel Herrera-Zaldivar, Centro de Nanociencias y Nanotecnología, Departamento de Fisica, UNAM

Osteoinductive Scaffolds Based on Magnetic and Luminescent Hydroxyapatite Nanostructures for use as Bone Regeneration Sensors / Andamios Osteoinductores Basados en Nanoestructuras de Hidroxiapatitas Magnéticas y Luminiscentes para uso como Sensores de Regeneración Ósea

Sarah Hake, Plant and Microbial Biology, UC Berkeley

María Jazmín Abraham Juárez, Biología Molecular, Instituto Potosino de Investigación Científica y Tecnológica A.C. (IPICYT)

Developmental Patterning and Pathogen Defense Correlation Revealed by Autoimmune Maize Mutants / Correlación Entre Patrón de Desarrollo y Defensa Contra Patógenos Revelada por Mutantes Autoinmunes de Maíz

John Haviland, Anthropology, UC San Diego

Telma Angelina Can Pixabaj, Cosmovisión y Lenguas de la Frontera Sur, CIMSUR, UNAMJohn Haviland, Anthropology, UC San Diego

Coexpression and Multimodality in Linguistic Interaction in Mesoamerica / La Coexpresividad y la Multimodalidad en la Interacción Lingüística en Mesoamérica

Gretchen Hofmann, Ecology, Evolution, and Marine Biology, UC Santa Barbara

Eugenio De Jesús Carpizo Ituarte, Oceanografía Biológica, UABC

Climate-Proofing an Aquaculture Species: A Collaborative ‘Proof of Concept’ Project on Oysters / Poniendo a Prueba del Clima a una Especie de Acuacultura: Proyecto Colaborativo de “Prueba de Concepto” en Ostiones

Ali Khademhosseini, Bioengineering, Chemical Engineering and Radiology, UC Los Angeles

Grissel Trujillo de Santiago, Departamento de Mecatrónica, Tecnológico de Monterrey

Development of a Technology to Fabricate Artificial Thick Perfusable Tissues in a Facile and Rapid Fashion / Desarrollo de una Tecnología para Fabricar Tejidos Gruesos Perfundibles de una Manera Fácil y Rápida

Louise Laurent, Department of Obstetrics, Gynecology, and Reproductive Sciences, UC

San Diego Silvia Alejandra García Gasca, Molecular and Cellular Biology, Centro de Investigación en Alimentación y Desarrollo

A First Approximation in the Study of Global DNA Methylation and Microbiome Composition in Women with Gestational Diabetes Mellitus / Primera Aproximación al Estudio de la Metilación Global Del ADN y la Composición del Microbioma en Mujeres con Diabete Melitus Gestacional

Kenneth Loh, Structural Engineering, UC San Diego

Arturo Baltazar, Robotics & Advanced Manufacturing, CINVESTAV

Portable and Wearable Soft-Material-Actuated Haptic System / Sistema Háptico Portable y Portátil Accionado con Material Suave

Patricia Manosalva, Microbiology and Plant Pathology, UC Riverside

Sylvia Fernández-Pavía, Instituto de Investigaciones Agropecuarias y Forestales, Universidad Michoacana de San Nicolás de Hidalgo

Genotypic and Phenotypic Characterization of Phytophthora Cinnamomi Populations from Mexico and California Associated with Avocado Root Rot / Caracterización Genotípica y Fenotípica de las Poblaciones de Phytophthora Cinnamomi de México y California, Causante de la Pudrición Radical del Aguacate

Alfredo Martínez-Morales, Center for Environmental Research and Technology, UC Riverside

Ivan Velasco, Neurociencias, Instituto de Fisiología Celular, UNAM Jesús Enrique Estudillo Hernández, Dirección de Invesigación, Instituto Nacional de Neurología y Neurocirugía

Hollow Titanium Dioxide Nanospheres as a Delivery System of Chemoattractant Factors for Human Dopaminergic Axons / Liberación de Factores Quimioatrayentes para Axones Dopaminérgicos Humanos por Nanoesferas Vacías de Dióxido de Titanio

Manuel Navedo, Pharmacology, UC Davis

Ricardo Espinosa-Tanguma, Fisiología y Biofísica, Universidad Autónoma De San Luis Potosí, Escuela De Medicina

Calcium Dynamics of Migrating Vascular Smooth Muscle Cells during Diabetic Hyperglycemia: Role of L-type Calcium Channels, STIM1, Orai1 and Homer Proteins / Dinámica del Calcio en Células de Musculo Liso Vascular en Migración durante Hiperglucemia Diabética: Papel de los Canales de Calcio Tipo L, STIM1, Orai1, y la Proteína Homer

Rasmus Nielsen, Integrative Biology, UC Berkeley

Diego Ortega Del Vecchyo, Laboratorio Internacional de Investigación sobre el Genoma Humano, UNAM

Analysis of the Impact of Demography and Natural Selection Jointly using Present-Day and Ancient Samples / Análisis del Impacto de la Demografía y la Selección Natural Utilizando Muestras del Presente y del Pasado

Victor Nizet, Pediatrics, UC San Diego

Ismael Secundino-Velázquez, Facultad de Odontología, Universidad De La Salle Bajío

Modulation of Inflammatory Response to Prevent Dental Implant Rejection / Control de la Inflamación para Prevenir el Rechazo a Implantes Dentales

Martha Lucia Orozco-Cárdenas, Botany and Plant Sciences, UC Riverside

Carla Vanessa Sánchez Hernández, Producción Agrícola, CUCBA, Universidad de Guadalajara

Overexpression of Herbivore-Responsive Genes in Husk Tomato (Physalis philadelphica) / Sobreexpresión de Genes de Respuesta a Herbivoría en Tomate de Cáscara (Physalis philadelphica)

Rudy Ortiz, Department of Molecular Cell Biology, UC Merced

José Guadalupe Soñanez Organis, Ciencias Químico Biológicas y Agropecuarias/Ciencas e Ingeniería, Universidad de Sonor

Role of Perilipin Family in the Cardiac Lipid Metabolism During Physiological Hypertrophy Induced by Pregnancy / Papel de la Familia de Perilipinas en el Metabolismo de Lípidos Cardiacos Durante Hipertrofia Cardiaca Fisiologica Inducida por Embarazo

Paivi Pajukanta, Human Genetics, UC Los Angeles

Alicia Huerta-Chagoya, Unidad de Biología Molecular y Medicina Genómica, CONACYT, Instituto Nacional de Ciencias Médicas y Nutrición

Teresa Tusié-Luna, Unidad de Biología Molecular y Medicina Genómica, Instituto Nacional de Ciencias Médicas y Nutrición

Salvador Zubirán, Instituto de Investigaciones Biomédicas, UNAM

The Effects of Maternal Obesity on the Transcriptome of Placenta and Adipose Tissue: Its Relation with the Newborn’s Phenotype / Los Efectos de la Obesidad Materna en los Transcriptomas de la Placenta y el Tejido Adiposo: Su Relación con el Fenotipo del Recién Nacido

Nicholas Pinter, Earth and Planetary Sciences, UC Davis

John M. Fletcher, División de Ciencias de la Tierra, Centro de Investigación Científica y de Educación Superior de Ensenada

Tectonics, Sea Level, and Interglacial Paleo-Environments of the Loreto Basin from Uplifted Coastal Terraces / Tectónica, Nivel del Mar y Paleoambientes Interglaciales de la Cuenca de Loreto desde Terrazas Costeras Elevadas

Jessica Purcell, Entomology, UC Riverside

Fernando Varela Hernández, Professional Institute of the Southern Region (IPRES), Universidad Autónoma del Estado de Morelos

On Genes, Behaviors, and Exploitation: Exploring the Causes and Consequences of Alternative Social Strategies along Latitudinal Gradients / Sobre Genes, Comportamientos y Explotación: Explorando las Causas y Consequencias de Estrategias Sociales Alternativas a lo Largo de Gradientes Latitudinales (GEORGE BROWN AWARD)

Kristen Ruegg, Institute for the Environment and Sustainability, UC Los Angeles

Richard Feldman, Recursos Naturales, Centro de Investigación Científica de Yucatán

Do Genomic Signals of Local Adaptation on the Breeding Grounds Predict Microclimate Associations on the Wintering Grounds? / ¿Pueden las Señales Genómicas de Adaptación Local a Sitios de Reproducción, Ayudar a Predecir Asociaciones Microclimáticas en Sitios Invernales?

Lynn Russell, Climate, Atmospheric Science & Physical Oceanography at Scripps Institution of Oceanography, UC San Diego

Victor Almanza, Modelado, LTM Center for Energy and the Environment A.C.

Air Quality Modeling Symposium and Training Workshop for Capacity Building in Mexico / Simposio y Taller de Capacitación de Modelación de la Calidad del Aire para la Creación de Capacidades en México

Laura Sales, Department of Physics & Astronomy, UC Riverside

Vicente Rodríguez-Gomez, Instituto de Radioastronomía y Astrofísica, UNAM

Galaxy Mergers in Different Environments: Using Cosmological Simulations to Solve the Mysteries of Diffuse Light in Galaxy Groups and Clusters / Fusiones de Galaxias en Distintos Ambientes: Usando Simulaciones Cosmológicas para Resolver los Misterios de la Luz Difusa en Grupos y Cúmulos de Galaxias

James Sickman, Environmental Sciences, UC Riverside

Vera Ingrid Gudrun Janine Tiesler, Facultad de Ciencias Antropológicas, Universidad Autónoma de Yucatán

Surviving the Maya Collapse in the Yucatan Peninsula: Reappraising Diets, Migrations, and Climate Changesthrough Isotopic Research / Sobreviviendo el Colapso Mayaen la Península de Yucatán: Una Revisión de Dietas, Migraciones y Cambios Climáticos a través de la Investigación Isotópica

Esteban Soto, Department of Medicine & Epidemiology, UC Davis

Francisco Neptalí Morales Serna, Unidad Mazatlán en Acuicultura y Manejo Ambiental, Centro de Investigación en Alimentación y Desarrollo A.C.

Efficacy of β Glucan as Immunostimulant to Pacific White Snook Centropomus Viridis / Eficacia del β Glucano como Inmunoestimulante para el Róbalo Centropomus viridis

Alejandro Sweet-Cordero, School of Medicine, UC San Francisco

Enrique Hernández-Lemus, Population Genomics, National Institute of Genomic Medicine (INMEGEN)

Computational Genomics for Personalized Breast Cancer Therapy / Genómica Computacional para la Terapia Personalizada del Cáncer de Mama

Kenichiro Tsukamoto, Anthropology, UC Riverside

Luis Barba, Instituto de Investigaciones Antropológicas, UNAM

Evaluating an Archetype of Classic Maya Marketplaces at El Palmar, Campeche, Mexico / Evaluando un Arquetipo de Mercados Mayas Clásicas en El Palmar, Campeche, México

Arturo Vargas-Bustamante, Health Policy and Management, UC Los Angeles

Mireya Vilar-Compte, Research Institute for Equitable Development (EQUIDE), Universidad Iberoamericana

How Anti-Immigrant Policies and Rhetoric Strengthen Access to Care Barriers Faces by Mexican Immigrants in the U.S. / Manera en que la Retórica y las Políticas Antiinmigrantes Fortalecen las Barreras de Acceso a los Servicios de Salud que Enfrentan los Inmigrantes Mexicanos en Estados Unidos

Oscar Vázquez Mena, NanoEngineering, UC San Diego

José Antonio Ávila Niño, Eduardo de Jesús Coutiño González, and Lilian Iraís Olvera Garza, Electroquímica, Centro de Investigación y Desarrollo Tecnológico en Electroquímica (CIDETEQ)

Green-Synthesized Semiconducting Polymers Blended with Quantum Dots for Organic Light Emitting Diodes (QOLEDs) / Polímeros Semiconductores Sintetizados a través de Química Verde Mezclados con Puntos Cuánticos para su uso en Diodos Orgánicos Emisores de Luz (QOLEDs)

Armando Villalta, Physiology and Biophysics and the Institute for Immunology, UC Irvine

Marco A. De León Nava, Departamento de Innovación Biomédica, DBEA, Centro de Investigación Científica y de Educación Superior de Ensenada (CICESE)

Harnessing Host-Pathogen Co-Evolution: Viral Proteins as Modulators of Helper and Regulatory T Lymphocyte Function / Aprovechando la Coevolución Entre Patógenos y Hospederos: Proteínas Virales como Moduladoras de la Función de Linfocitos T Colaboradores y Reguladores

Kerstin Wasson, Ecology and Evolutionary Biology, UC Santa Cruz

Julio Lorda Solórzano, Facultad de Ciencias, Universidad Autónoma de Baja California

International Olympia Oyster Network: Collaborative Research and Assessment of Management Goals in Baja California, Mexico / Red Internacional del Ostión Olympia: Investigación Colaborativa y Evaluación de Objetivos para su Manejo en Baja California, México

Ke Xu, Chemistry, UC Berkeley

Arturo Jiménez-Sánchez, Química Orgánica, UNAM

Development of Chemical Probes for Mitochondrial Dynamics Using Functional Super-Resolution Microscopy / Desarrollo de Sondas Químicas para la Dinámica Mitocondrial Mediante Microscopía de Superresolución Funcional

Omar Yaghi, College of Chemistry, Department of Chemistry, UC Berkeley

Edmundo Guzmán Percástegui, Instituto de Química, UNAM

Water-Soluble Cages that Transform into Multifunctional Metal-Organic Frameworks for Aqueous Applications / Cajas Solubles en Agua que se Transforman en Armazones Metal-Orgánicos Multifuncionales para Aplicaciones Acuosas

Jin Z Zhang, Biomolecular Science & Engineering, UC Santa Cruz

Tzarara López Luke, Ceramicos y Refractarios, UMSNH, Instituto de Investigaciones en Metalurgia y Materiales

Enhancing the Stability, Efficiency, and Color Tunability of Inorganic and Hybrid Perovskite Quantum Dots for LED Applications / Incremento de la Estabiliad, Eficiencia y Tunelamiento de Color de Puntos Cuanticos de Perovskita Inorganica e Hibridas para Aplicaciones en (Diodos Emisores de Luz) LEDs

Haofei Zhang, Department of Chemistry, UC Riverside

Omar Amador-Muñoz, Ciencias Ambientales, UNAM

Comprehensive Analysis of the Organic Aerosol Molecular Composition at a Receptor Sitein Mexico City and Their Role in Urban Air Quality / Análisis Integral de la Composición Molecular de Aerosoles Orgánicos en un Sitio Receptor en la Ciudad de México y su Impacto en la Calidad del Aire Urbano

Marine bacteria are the most abundant organisms in the ocean, influencing the global biogeochemical cycles of nutrients with significant effects on marine food web dynamics and climate. Upwelling regions, in particular within the California Current System, are some the most productive regions of the world oceans having a major impact in resource availability in the coastal ocean. However, most studies trying to understand the role of bacteria in carbon and nutrient cycling in marine environments have used indirect approaches, including metagenomics and metatranscriptomics in natural communities of bacteria, which represent only snapshots of the microbial community at a single given time of the year. Although omics data have been valuable to identify the bacterial groups present and their genomic potential, they are not suitable to study the physiology and activity patterns of those organisms. To circumvent that limitation, we propose to use cultures of marine bacteria isolated from two different regions within the Southern California Bight within the California current system (Scripps pier in Southern California and Bahia Salsipuedes in Baja California). These environments are perfect models for understanding upwelling systems, which comprise about 2% of the global ocean but provide about 20% of the wild marine capture fisheries. Our goal is to characterize diverse bacterioplankton strains representative of these areas to understand their physiology and rates of carbon and nutrient processing under different environmental conditions. These data can help to predict the response of marine bacteria to changing environmental conditions, especially those caused by climate change. This seed proposal brings together scientists and their students in a binational interdisciplinary manner. The co-PI in Mexico (Gómez-Consarnau) has extensive expertise studying marine bacteria in seawater, including their growth and physiological characteristics combined with chemical measurements. The co-PI in the US (Azam), has developed over the years numerous protocols to measure bacterial activity in seawater as well as established one of the most successful marine microbiology laboratories in the world, both in publications and graduate students output. Combining the complementary PIs’ expertise will result in future collaborative research projects, relevant discussions and other interactions that involve not only the PIs but also graduate students at both institutions (CICESE and SIO UC San Diego).

Farooq Azam, Marine Biology Research Division – Scripps Institution of Oceanography,
UC San Diego
Laura Gómez-Consarnau, Ocenografía Biológica, CICESE

Fine aerosol particles originating directly from sources as primary aerosols or forming secondarily in the atmosphere from gas to particle conversion processes, have negative environmental and human health impacts. In this proposal, we combine online and offline measurements of aerosol composition during several months (September-December) to gain more detailed understanding of the seasonality and influence of emissions and mixing of urban and natural sources on fine aerosol particles, at a site within the Regional Mixed Layer of the Mexico City Metropolitan Area. We will use offline extractive electrospray ionization mass spectrometry technique, along with an online bulk aerosol composition (Aerosol Mass Spectrometry) data to characterize the organic aerosols in the site, in order to improve our understanding of the interactions of different emission sources on air quality in the region and provide modelers insights on how to improve model predictions of OA. This project will set the basis for a collaboration based on the use of infrastructure and analytical capabilities of both PIs for the analysis of OA in other important, yet unstudied, regions in Mexico. In addition, the expected participation of a Mexican PhD student will reinforce the human resources development and capabilities in Mexico.

Roya Bahreini, Environmental Sciences, UC Riverside
Dara Salcedo González, UMDI-Juriquilla Facultad de Ciencias, UNAM

Climates are changing rapidly in response to increased global carbon emissions. Species and communities are influenced by these climate changes in many ways and how they respond will shape the future pattern of diversity and ecosystem services, and impact the evolutionary potential of species into the future. Gaining a better understanding of the impact of climate change on species and communities is thus a top priority. Contemporary climate change responses only capture part of the story, however; species have been responding to climate change in many ways throughout their evolutionary histories. In this proposal, we aim to integrate data on fossil mammal communities found throughout North and Central America to gain a fuller understanding on how climate has influenced biodiversity over the last 21,000 years. Data from the United States and Canada are currently stored in a separate database (the Neotoma Paleoecology Database) from the data from Mexico (the Quaternary Mexican Mammals Database), and data from further south in Central America is absent from both. In order to gain a fuller picture of mammalian range shifts and community change throughout the western hemisphere, we first need to integrate the data resources onto a common platform to enable this work.

Jessica Blois, Life and Environmental Sciences, UC Merced
Joaquín Arroyo-Cabrales, Subdirección de Laboratorios y Apoyo Académico,
Instituto Nacional de Antropología e Historia

The goal of this project is to develop a long lasting collaboration between UC Davis and CIQA, Mexico, for the development of materials for advanced energy solutions. The project will target student and researcher exchanges and the seed project will be focused on the research and development of an ultra-light sandwich structure with potential use in vertical-axis wind turbines, specifically those with helical blades. The sandwich structure will consist in a foam core of high-density polyethylene (HDPE) reinforced with boron carbide (B4C) nanoparticles and face sheets of a carbon fiber (CF)/epoxy composite reinforced with B4C. Different from the published works were B4C are typically used without any surface treatment, in this project the surface of B4C will be tailored by in situ plasma polymerization of ethylene and an aminosilane to be compatible with HDPE and the epoxy matrices, respectively. The scientific goal is to improve mechanical performance of HDPE and CF/epoxy materials without heavily compromising weight by exploiting the low density of B4C and its impressive mechanical features. Moreover, B4C shall decrease degradation by radiation since boron atoms can absorb irradiation and avoid major damages through the structure. This work will serve as platform for future larger proposals to be worked together.

Ricardo Castro, Materials Science and Engineering, UC Davis
José de Jesús Ku-Herrera and Gustavo Soria-Arguello, Síntesis de Polímeros, CONACYT-Centro de Investigación en Química Aplicada

Plants have developed complex mechanisms to cope with environmental stresses, including the plant-pathogen interactions which are intimately coordinated by complex signaling networks of the so called “trio signaling messengers”: reactive oxygen species (ROS), electrical signals and calcium. Plant defense responses have been subject to deep and genome-saturating conventional genetic analysis, nevertheless the identification of mutants related to ROS-triggered defense response is still limited. One explanation of this phenomena, is that traditional genetic analysis reaches its limits for several reasons, including the genetic redundancy and the pleiotropic phenotypes, such as lethality or infertility that might result in the genetic modification of essential genes. To avoid these limitations, it has been proposed to use of chemical genetic screens that combine a biological screening with small chemicals that could potentially modify gene products of a specific signaling pathway. In this project, we propose to characterize the ROS-dependent signaling pathway performing a chemical genomic screening. In particular, we will study the modification of ROS during the compatible interaction between Arabidopsis thaliana and the second most important pathogen in the agriculture: the necrotrophic fungus Botrytis cinerea.

Sean Cutler, Department of Botany and Plant Sciences, UC Riverside
Mario Serrano, Center for Genomic Sciences, UNAM

Diabetes Mellitus (DM) is a growing health care problem resulting in significant cardiovascular disease. Diabetic heart disease includes decreased cardiac contractile function in the absence of ischemia. The majority of diabetic patients die of cardiovascular disease. DM is considered an inflammatory disease and macrophages from adipose tissue are involved in the pathophysiology. Adipose tissue macrophages (ATMs) secrete exosomes (Exos), endosome- derived membrane vesicles carrying microRNA, protein, and other bioactive molecules. ATM-Exos secreted from DM individuals contain harmful bioactive molecules that impart maladaptive effects in other tissues. However, whether ATM-Exos from healthy individuals can alleviate diabetic cardiac disease is unknown. The hypothesis to test in this proposal is that ATM-Exos in obesity or DM carry diverse deleterious bioactive molecules that disseminate maladaptive consequences to other organs including the heart. In contrast, ATM-Exos from healthy mice carry beneficial molecules that are able to counteract diabetic cardiac disease and improve cardiac performance when transferred to diabetic mice. All of our approaches are innovative and will generate new knowledge in the field and new therapeutic targets to alleviate diabetes-related cardiac dysfunction. In addition, participation of researchers and students from institutions in the U.S. and Mexico will strengthen the potential success of this project and future collaborations

Wolfgang Dillmann, Medicine, UC San Diego
Julieta Anabell Díaz Juárez, Farmacología, Instituto Nacional de Cardiología

Federal deportation policies have an especially pronounced effect in California, where almost 2 million children live with at least one undocumented family member. A fifth of the state’s juvenile population is vulnerable to the deportation of a parent. These policies disproportionately affect Mexico as well, as three-quarters of the immigrants deported from the United States are Mexican nationals. This study based on fieldwork in San Diego and Tijuana examines how migrant families and public institutions on both sides of the border attempt to manage the effects of mass parental deportation from California to Mexico. Drawing on 40 expert interviews and five family case studies, we assess the implementation of California’s 2012 “Reuniting Immigrant Families Act,” which addresses the reunification challenges of immigrants in the child welfare system. The project will yield evidence-based recommendations in a bilingual report and binational workshops aimed at informing policymakers in California and Mexico on how coordination across jurisdictions and agencies may improve policy responses.

David FitzGerald, Center for Comparative Immigration Studies, UC San Diego
Rafael Guadalupe Alarcón Acosta, Departamento de Estudios Sociales,
El Colegio de la Frontera Norte

Papaya is an economically important fruit due to its high nutritional and nutraceutical value. Mexico occupies third place in the global production, and it is the primary exporter to the United States mark

Most simple viruses consist of a coat protein that specifically packages its own genome into a nanoparticle. In last decades, studies reconstituting viruses in the laboratory from purified components have contributed largely to advance our understanding about viruses and made possible their biotechnological use. Recently, the design of artificial viruses has emerged and it represents a unique opportunity to further advance the knowledge about viruses. Artificial virus-like particles based on simple and programmable proteins have been used as a model for studying and probing virus assembly and internalization of nucleic acids into the interior of cells. This project aims to engineer one of those proteins to make it able to package with high affinity a RNA and DNA molecules encoding its own amino acid sequence. This artificial virus would represent a breakthrough in the area and be a better model in synthetic virology. A second aim is to elucidate the resulting protein-DNA/RNA structures using high resolution cryogenic imaging methods. The phenotype-genotype linkage supplemented with structural details of the artificial virus will allow future directed evolution of the protein into virus-like capsids for advanced biotech applications such as nano-vaccines or “smart” delivery systems, and will advance our general understanding about viruses.

et, with a value of more than $100 million dollars. Papaya fruit is a highly perishable and very susceptible to postharvest fungal infections, including anthracnose, which is mainly caused by Colletotrichum gloeosporioides and Colletotrichum truncatum. Several studies have shown that the resistance of some fruits to fungal pathogens is associated with the composition of the cuticle. Recent research by our group found one genotype with resistance to C. gloesporioides y C. truncatum. Currently, there are no molecular studies of the responses of papaya to anthracnose, the chemical composition of the cuticle in papaya fruits is unknown, and there is a lack of knowledge about the role of cuticular compounds in resistance against C. gloesporioides and C. truncatum. Here we propose to investigate the cuticular resistance of papaya fruits to Colletotrichum gloeosporioides and Colletotrichum truncatum. by: Analyzing the cuticle structure and composition of papaya genotypes displaying resistance and susceptibility to anthracnose, and determining molecular responses associated with the cuticular resistance of papaya fruit to Colletotrichum gloeosporioides and Colletotrichum truncatum

William Gelbart, Chemistry & Biochemistry, UC Los Angeles
Armando Hernández García, Instituto de Química – Química de Biomacromoléculas,
UNAM

In this project, we propose to synthesize and characterize nanostructures of hydroxyapatite (HAp) doped with magnetic (Fe and Cr) and rare-earths (Eu, Yb, Ce, Tb, Tm, and Er) impurities, which will be incorporated in bone scaffolds made of collagen. Given that such scaffolds will be used in bone regeneration treatments (synthetic bone grafts), in this project we will study their role in the growth of osteoblast cells. During its manufacture, the surface of the scaffolds will be coated with the nanostructures of HAp, which, being one of the principal components of bone, is expected to favor the proliferation of osteoblast cells. Eventually, because the body can completely absorb these scaffolds, in-vitro tests will be done to estimate the time and conditions under which this occurs. In order to build such scaffold-HAp assemblies, a detailed study of both the conditions required for the synthesis of the HAp nanostructures, as well as their physicochemical properties, will be carried out. Its crystallinity, morphology, composition, crystalline defects, luminescence and valence state of the incorporated impurities will be studied. For this, we will use mainly the techniques of DLS (Dynamic Light Scattering), SEM (Scanning Electron Microscopy), TEM (Transmission Electron Microscopy), AFM (Atomic Force Microscopy), CL (Cathodoluminescence), XPS (X-ray Photoelectron Spectroscopy), EELS (Energy Electron Loss Spectroscopy) and EPR (Electron Paramagnetic Resonance). For the synthesis of HAp nanostructures, the combustion method and the hydrothermal method will be used to obtain different morphologies. The magnetic and luminescent properties of these HAp permit us the scaffolds as sensors that will act as contrast agents for magnetic resonance tomographies and as fluorescent probes in bone regeneration treatments.

In this project, we propose to synthesize and characterize nanostructures of hydroxyapatite (HAp) doped with magnetic (Fe and Cr) and rare-earths (Eu, Yb, Ce, Tb, Tm, and Er) impurities, which will be incorporated in bone scaffolds made of collagen. Given that such scaffolds will be used in bone regeneration treatments (synthetic bone grafts), in this project we will study their role in the growth of osteoblast cells. During its manufacture, the surface of the scaffolds will be coated with the nanostructures of HAp, which, being one of the principal components of bone, is expected to favor the proliferation of osteoblast cells. Eventually, because the body can completely absorb these scaffolds, in-vitro tests will be done to estimate the time and conditions under which this occurs. In order to build such scaffold-HAp assemblies, a detailed study of both the conditions required for the synthesis of the HAp nanostructures, as well as their physicochemical properties, will be carried out. Its crystallinity, morphology, composition, crystalline defects, luminescence and valence state of the incorporated impurities will be studied. For this, we will use mainly the techniques of DLS (Dynamic Light Scattering), SEM (Scanning Electron Microscopy), TEM (Transmission Electron Microscopy), AFM (Atomic Force Microscopy), CL (Cathodoluminescence), XPS (X-ray Photoelectron Spectroscopy), EELS (Energy Electron Loss Spectroscopy) and EPR (Electron Paramagnetic Resonance). For the synthesis of HAp nanostructures, the combustion method and the hydrothermal method will be used to obtain different morphologies. The magnetic and luminescent properties of these HAp permit us the scaffolds as sensors that will act as contrast agents for magnetic resonance tomographies and as fluorescent probes in bone regeneration treatments.

Olivia Graeve, Mechanical and Aerospace Engineering, UC San Diego
Manuel Herrera-Zaldivar, Centro de Nanociencias y Nanotecnología, Departamento de Fisica, UNAM

Maize is the most widely grown crop in the world. It is a model plant for developmental genetics in the grasses. However, very little is known about signaling mechanisms that coordinate growth, development, and defense response in maize. Thus, advances in this field are promising to achieve improved inbreds adapted to different microclimates. We are interested in autoimmune mutants, which show hyperactivation of immune system in the absence of infection. Autoimmunity is known to cause strong developmental defects, but little is known about how the immunity regulates development. nod and Lgn-R mutant phenotypes show a striking dependence on inbred background and temperature, which makes them excellent tools to explore inbred breeding in different microclimates. Their transcriptomes show constitutive upregulation of the pathogen response, suggesting that LGN and NOD are part of the signaling coordinating development and defense response. We propose to investigate the molecular mechanisms by which crop plants respond to pathogen and what roles temperature and genetic background play by using CoIP, LC-MS/MS, antibody production, RNAseq and plant infection assays to test immune response in different inbreds and mutants. Our results will expand information gained in important cereal crops, and will generate genetic tools to interrogate immune signaling and pathogen responses in maize.

Sarah Hake, Plant and Microbial Biology, UC Berkeley
María Jazmín Abraham Juárez, Biología Molecular, Instituto Potosino de Investigación
Científica y Tecnológica A.C. (IPICYT)

That human communication—including spoken language—involves multiple simultaneous channels or modalities in addition to speech is an ancient idea that has only recently received serious attention from scholars of language and social interaction. Recent advances in the study of multimodality or co-expressivity often involve research in indigenous languages of the Americas, but despite extensive investigation by native and non-native researchers alike, little work by a new generation of scholars includes serious study of how different aspects of what have been called “composite utterances”—including speech (or sign), gesture, bodily configuration, gaze, and touch—coalesce to enable communicative action. This project will assemble a team of graduate students and experienced scholars, whose work encompasses a variety of Mesoamerican languages, and whose field experience includes attention to multimodal, interactive material through video and audio recording. Via a series of three weeklong workshops, to be held over the 18 months of the grant period at CIMSUR (UNAM) in Chiapas, Mexico, we will explore the notion of multimodal coexpression in communicative interaction, apply it to our various field projects, and produce both an edited volume of research and an interactive web resource to promulgate the theoretical framework and empirical results of our collaboration.

John Haviland, Anthropology, UC San Diego
Telma Angelina Can Pixabaj, Cosmovisión y Lenguas de la Frontera Sur, CIMSUR, UNAM

The goal of this collaborative project is to explore whether an important aquaculture species, the Pacific oyster, can be “climate-proofed”. Using research facilities at UABC, we will condition adult oysters to high temperatures, and then test whether their progeny are more tolerant of heat stress as embryos and larvae. Conceptually, our approach relies on transgenerational plasticity (TGP) as a means to “heat harden” early stage oysters, with the idea that such priming of the progeny via adult conditioning will result in hardier spat and juvenile oysters in an aquaculture setting in the future. Experimentally, our goal is to assess performance of the progeny using methods that assess metabolism, and growth. In addition, we plan to use molecular tools where we will ask whether the thermal history of the oyster broodstock is transferred to their offspring via an epigenetic response. The latter will be performed using a methylation-sensitive polymorphism amplification (MSAP) assay developed in the lab at UC Santa Barbara. The aquaculture work and physiological measurements will be conducted at UABC, and MSAP analyses will be conducted at UC Santa Barbara. We plan the involvement of students and early career scientists from both campuses, facilitated by a 1-week workshop on marine environmental epigenetics at UC Santa Barbara.

Gretchen Hofmann, Ecology, Evolution, and Marine Biology, UC Santa Barbara
Eugenio De Jesús Carpizo Ituarte, Oceanografía Biológica, UABC

The limited capabilities to manufacture clinically-relevant sizes of tissues is a major drawback of tissue engineering technologies nowadays. Fabricating thick tissues (thicker than 200 mm) is challenging due to mass transfer limitations. In the past few years, efforts have been made to develop strategies to fabricate perfusable and vascularized thick tissues. Despite some successful accomplishments, there is still a need of strategies capable of developing prefusable micro-structures in a facile and rapid fashion.

Here, we propose the use of 3D-continous-chaotic-bioprinting technology to create hydrogel constructs with perfusable inner-microchannels in a facile and rapid manner. Three-D continous- chaotic-bioprinting is highly efficient in generating hydrogel fibers with fine internal microstructure (i.e., fibers of diameter = 1 mm, with inner-microstructures of 10 mm thick in their cross-section). In this project, we will use two different types of bioinks: cell-laden crosslinkable- hydrogels, and sacrificial hydrogels, so that the sacrificial bioink will leave an empty microchannel inside the cell-laden fiber. Our bioprinted constructs will be assessed in terms of their architecture, (validation that the microchannel was successfully made without affecting the mechanical integrity of the fiber), the diffusional permeability, and biological performance (cell viability, cell proliferation, expression of biological markers).

Ali Khademhosseini, Bioengineering, Chemical Engineering and Radiology, UC Los Angeles Grissel Trujillo de Santiago, Departamento de Mecatrónica, Tecnológico de Monterrey

Gestational Diabetes Mellitus (GDM) is a condition characterized by hyperglycemia and insulin resistance that is similar to Type-2 Diabetes (T2D), but is diagnosed in pregnant women who were normoglycemic prior to pregnancy. The incidence of pregnancies affected by GDM is increasing, and varies substantially depending on the diagnostic criteria used and the ethnic composition of the study population. Although the incidence is 3-6% worldwide, it is much higher in certain populations, including 8 to 12% in Mexico, and 16% in Native American women. Many cases of GDM are not diagnosed or remain untreated, leading to suboptimal clinical outcomes, because the offspring of women with GDM have an elevated risk of fetal overgrowth and associated perinatal complications, such as birth injury and neonatal jaundice and hypoglycemia, as well as obesity, T2D, and metabolic and cardiovascular diseases later in life. This link between the intrauterine environment and postnatal health suggests that antepartum environmental exposures may be encoded in the fetal and placental epigenome and thus influence the long-term health of the baby. In addition, alterations in maternal microbiome composition that are associated with GDM may influence the microbiome of the baby and mediate the observed increased risk of metabolic disorders later in life. Motivated by the overarching need for obstetrician-gynecologists to better understand GDM in order to provide appropriate management to affected pregnancies and thus optimize outcomes in the offspring, this project aims to map the relationships between GDM, global DNA methylation, and the microbiome in a Mexican population of pregnant women. To this end, the UC San Diego School of Medicine and the Research Center for Food and Development in Mexico are combining resources and expertise to carry out this seed project and establish a collaboration that will enable future endeavors in this area.

Louise Laurent, Department of Obstetrics, Gynecology, and Reproductive Sciences, UC San Diego Silvia Alejandra García Gasca, Molecular and Cellular Biology, Centro de Investigación en Alimentación y Desarrollo

Virtual, augmented, and mixed realities provide limitless interactive experiences for people. Today, user feedback through haptic perception has been primarily based on vibration- based systems that cannot accurately convey contact force and pressure sensations. The area of soft robotics as an actuator opens new opportunities, but current pneumatically actuated systems are not suitable for realizing wearable systems. Thus, the goal is to design and demonstrate a portable, wearable, haptic glove that integrates a novel actuation mechanism for imparting controllable contact force/pressure feedback. A focus is to design soft polymer structures with an embedded liquid source that can be leveraged to change phase. When ultrasonic waves excite the encapsulated liquid, atomization causes the liquid to vaporize while locally expanding the structure. Four main tasks are planned. First, a method for achieving ultrasonic atomization of minute amounts of liquid stored in foam will be tested. Second, soft structures will be designed to achieve bending motion/pressure when actuated by atomization. Third, thin film sensors will be integrated for providing real-time motion sensing capabilities. Finally, a portable control system will be assembled to receive sensing feedback, process data using closed-loop feedback control, and control actuation of the haptic system.

Kenneth Loh, Structural Engineering, UC San Diego
Arturo Baltazar, Robotics & Advanced Manufacturing, CINVESTAV

Phytophthora root rot (PRR), caused by Phytophthora cinnamomi (Pc), is one of the most devastating avocado diseases worldwide. PRR severely reduces fruit yield and quality and, when unmanaged, can completely destroy avocado orchards. It has been suggested that more virulent and fungicide insensitive Pc isolates have been introduced from Mexico into Southern California. This project aims to test this hypothesis by characterizing and comparing the current Pc populations between Mexico and U.S., the top two global avocado producers. Isolates will be collected from avocado orchards in Michoacan, Mexico and in California. Genotypic characterization of Pc isolates will be based on Genotyping By Sequencing (GBS) analyses, and phenotypic characterization will be on fungicide sensitivity and virulence tests. GBS will vastly increase the resolution to study the Pc population genetics compared to the methods used in previous studies. This study enables us to identify genetically and phenotypically diverse isolates that can be used to design isolate/clade-specific diagnostic tools and to screen avocado germplasm collections to select Pc resistant rootstocks. In summary, our results will aid the design of appropriate measures for PRR management increasing the avocado production, profitability, and competitiveness by reducing losses to this devastating disease.

Patricia Manosalva, Microbiology and Plant Pathology, UC Riverside
Sylvia Fernández-Pavía, Instituto de Investigaciones Agropecuarias y Forestales, Universidad Michoacana de San Nicolás de Hidalgo

This proposal joins together co-PIs Dr. Iván Velasco at the Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico (IFC-UNAM) and Dr. Enrique Estudillo at the Instituto Nacional de Neurologia y Neurocirugia (INNN) along with co-PI Dr. Alfredo Martínez-Morales at University of California Riverside (UCR) as part of a multidisciplinary project to investigate the potential use of hollow TiO2 nanospheres (HTiO2NS) as an effective and stratregic delivery system to release the chemotropic protein Semaphorin 3C (Sema 3C) to attract axons of dopaminergic neurons differentiated from human pluripotent stem cells. In vitro experiments using microfluidic devices will be carried out to evaluate the efectiveness of the HTiO2NS as a delivery system for Sema 3C to guide the axons of transplanted dopaminergic neurons (DN) towards achieving proper innervation within the brain in a rodent model of Parkinson Disease (PD). The Co-PI Martinez-Morales possess the expertise and required infrastructure to engineer, synthesize and characterize the HTiO2NS and to evaluate their capacity to release Sema 3C. The co- PIs Velasco and Estudillo have expertise and infrastructure for differentiating human pluripotent stem cells towards DN which will be used to perform axonal growth and attraction assays to evaluate the efficiency of HTiO2NS loaded with Sema 3C.

Alfredo Martínez-Morales, Center for Environmental Research and Technology, UC Riverside Ivan Velasco, Neurociencias, Instituto de Fisiología Celular, UNAM
Jesús Enrique Estudillo Hernández, Dirección de Invesigación, Instituto Nacional de Neurología y Neurocirugía

Diabetes mellitus (DM) is a chronic disease with high prevalence and incidence worldwide. One of the main complications of DM is acute myocardial infarction (AMI). The current treatment for a patient suffering of an AMI is pharmacological and/or revascularization through an artery bypass graft surgery or the placement of a metallic tube call “stent” that re- establish the myocardial blood flow. However, patients treated in in this way suffer from arterial restenosis because the stent induces the release of chemotactic factors like PDGF and thrombin that triggers vascular smooth muscle cell migration. Vascular smooth muscle migration is highly dependent on calcium influx, but the mechanisms are not well understood. The main goal of this application is to examine cytosolic calcium dynamics and the expression pattern of specific calcium permeable proteins that are known to mediate calcium signals during diabetic hyperglycemia. Our central hypothesis is that the activity of the calcium permeable channels (L- type calcium channel and STIM1/Orai1 channel) as well as the function of the scaffolding protein Homer 1 is altered in response to elevated glucose that mimics the hyperglycemic state in diabetes. This study is significant as understanding mechanisms underlying changes in calcium dynamics that contribute to vascular smooth muscle migration during diabetic hyperglycemia may identify novel targets that can be used for pharmacological intervention to treat vascular complications such as arterial restenosis. Innovative and contemporary methods, well-established in our labs, will assure completion of the proposed aims. The support of this UC Mexus award will facilitate the acquisition of preliminary data that will then be used for R01 applications to the NIH.

Manuel Navedo, Pharmacology, UC Davis
Ricardo Espinosa-Tanguma, Fisiología y Biofísica, Universidad Autónoma De San Luis Potosí, Escuela De Medicina

The ability to sequence genomes from ancient humans and hominins is one of the most important technological advances of the last fifteen years to unravel fragments of our history that were impossible to obtain only using modern samples. This has allowed us to understand how people migrated to different places on the world and how advantageous variants increased their frequency over time. However, genomic data from ancient samples often has very low coverage and does not allow us to precisely determine the genotype at each position in the genome. Therefore, the most used approach is to randomly sample one allele per site and then do all the subsequent inferences using this sampled allele. This approach discards genomic information that could be used to make more powerful inferences. Here we propose to develop new methodologies that efficiently use all the genomic information from an ancient sample. We propose new methods to infer past population history, the strength of natural selection, and to infer changes in gene flow across space and time. We expect that our methodologies will be useful to analyze ancient genomic information from other species than humans.

Rasmus Nielsen, Integrative Biology, UC Berkeley
Diego Ortega Del Vecchyo, Laboratorio Internacional de Investigación sobre el Genoma Humano, UNAM

Peri-implant mucositis is a reversible inflammatory lesion of the mucosa surrounding a dental implant without the loss of supporting alveolar bone. If inflammation is not abrogated, bacteria will accumulate around the dental implant, causing destruction of supporting tissue (alveolar bone) in a process known as peri-implantitis. Upon dental implant placement, the underlying tissue -the alveolar bone- will be remodeled, resulting in new bone that will be osseo- integrated to the cylindrical titanium screw-thread implant. Smoking or the prior presence of periodontitis are risk factors for peri-implant mucositis and peri-implantitis. Even in the absence of risk factors, peri-implantitis disease can be seen in healthy individuals. Evidence suggests the presence of an infiltrate of leukocytes during peri-implant mucositis, predominantly of lymphoid and granulocytic lineages. Such infiltrated cells induce the release of TNF-α, IL-1β and IL-8. Elastase-positive leukocytes are found in the margin of the barrier epithelium and connective tissue, suggesting the presence of neutrophils. Together, migrating leukocytes and pro- inflammatory cytokines contribute to boost the inflammatory response causing tissue damage. Thus, resolution of inflammation would be critical for preventing cellular injury.

Inhibitory CD33-related Siglecs are mammalian immune cell receptors that dampen leukocyte activation upon engagement of sialic acid-terminated glycans. Human neutrophils constitutively express Siglec-9 and Siglec-5. It is reasonable to hypothesize that the expression of inhibitory Siglecs are reduced in peri-implantitis lesions causing strong neutrophil reactivity. Upon initial inflammation, bacteria from oral biofilm spread and colonize the soft tissue around implant promoting peri-implant response exacerbation. Staphylococcus aureus is frequently isolated from titanium implants from peri-implantitis lesions, suggesting its prominent role as a pathogen involved in implant adherence. Specific aims of this proposal include: identify the expression of inhibitory Siglecs on human neutrophils from peri-implant mucositis and peri-implantitis lesions; identify the presence of 13 pro-inflammatory cytokine and chemokines from peri-implant mucositis and peri-implantitis lesions; evaluate the production of neutrophil extracellular traps (NETs) and association with tissue damage; and finally, by generating isogenic mutant strains of S. aureus, identify the relevant staphylococcal virulence factor(s) involved in colonization of titanium implants and the corresponding inflammatory immune response.

Victor Nizet, Pediatrics, UC San Diego
Ismael Secundino-Velázquez, Facultad de Odontología, Universidad De La Salle Bajío

Mexican husk tomato (Physalis philadelphica) is a plant of the Solanaceae family bearing small spherical green-purple fruits that are highly consumed as part of the Mexican diet and folk medicine since prehispanic times. Husk tomato is produced through Mexico in traditional and intensive agroecosystems, where several insect herbivore pests seriously affect yield and fruit quality. The goal of this research is to overexpress P. philadelphica herbivore- inducible genes, threonine deaminase (PpTD) and leucine aminopeptidase (PpLAP) in husk tomato plants, as a strategy to understand their functional contribution to the herbivore defense in this species. The specific objectives are: 1) To isolate the full-length cDNA of PpTD and PpLAP and clone them in plasmid transformation vectors, 2) To generate P. philadelphica transgenic plants constitutively overexpressing PpTD and PpLAP genes, 3) To perform molecular and biochemical analysis to determine PpTD and PpLAP expression levels and enzymatic activity in transgenic lines and 4) To evaluate the resistance in overexpressing PpTD and PpLAP plants to insect herbivory by Manduca sexta larvae. The results of this research will help understand the functional contribution of PpTD and PpLAP genes to P. philadelphica defense against insect pest attacks, representing the first step toward a full characterization of the defense response in this species. This information is crucial to design novel strategies for pest control, which should comprise the up-regulation of endogenous defense mechanisms. Results will be available openly through meeting presentations and publications.

Martha Lucia Orozco-Cárdenas, Botany and Plant Sciences, UC Riverside
Carla Vanessa Sánchez Hernández, Producción Agrícola, CUCBA, Universidad de Guadalajara

Perilipin family proteins (PLIN) regulate lipid storage metabolism through coating of intracellular neutral lipids in structures called lipid droplets (LD). PLIN proteins differ in size, affinity for LD, tissue expression, transcriptional regulation, and unbound stability. PLIN5 is expressed mainly in cardiac muscle, and its main function is to protect the heart from oxidative damage by sequestering fatty acid (FA) and by forming lipid barriers of uncontrolled mobilization of triacylglycerols, and excessive release and oxidation of FA. However, the participation of the PLIN family in physiologic hypertrophy induced by pregnancy and its reversible process (postpartum) are not well defined. Because pregnancy induces physiologic hypertrophy and is a natural reversible process, the in-depth analyses of the biochemical and physiological mechanisms of substrate metabolism that occur before, during and after pregnancy provide an ideal opportunity to study a natural biological process that does not require genetic modification or exogenous manipulation of the behavior to explore the mechanisms of the pathological hypertrophy associated with the reprogramming of cardiac metabolism. Furthermore, the study of rats, which have short-term and easy to track pregnancies, make them logistically accessible for conducting the proposed research. Therefore, the goal of this proposal is to evaluate the contributions of the Perilipin family axis activation before, during, and after pregnancy to lipid metabolism in the left ventricle, which is most susceptible to hypertrophy. The specific aims will address the central hypothesis that PLIN family are activated to coordinate the cardiac lipid metabolism during pregnancy and that their activation is reversible during postpartum to the maintain cardiac function and structure.

Rudy Ortiz, Department of Molecular Cell Biology, UC Merced
José Guadalupe Soñanez Organis, Ciencias Químico Biológicas y Agropecuarias/Ciencas e Ingeniería, Universidad de Sonora

Obesity is the main risk modifiable factor for the development of multiple diseases. Specifically, maternal obesity not only triggers adverse effects in the mother-fetus pair, but also in subsequent generations. The functional tissue-specific mechanisms by which effects are caused are still unclear. Besides the unquestionable participation of maternal adipose tissue in obesity- derived fetal complications, the placenta is another important tissue. It is the interface between the mother-fetus environment, thus playing a central role in how maternal obesity influences the offspring’s programming. GWAS have reported the participation of risk genetic variants for adipose tissue accumulation and it is recognized that in genetically susceptible women to body gain, pregnancy represents a major metabolic challenge. Mexicans harbor a strong genetic contribution for the development of metabolic diseases. Given its high Native American ancestry proportion, Mexican population own genetic variants that occur at very low frequency or that are absent in other populations but have higher effect sizes. The main objective of this proposal is to perform an integrative assessment of the genome-wide genetic and transcriptomic profiles of adipose tissue and placenta in pregravid lean and obese Mexican women, as well as the evaluation of their impact on the newborn anthropometric and metabolic characteristics.

Paivi Pajukanta, Human Genetics, UC Los Angeles
Alicia Huerta-Chagoya, Unidad de Biología Molecular y Medicina Genómica, CONACYT, Instituto Nacional de Ciencias Médicas y Nutrición
Teresa Tusié-Luna, Unidad de Biología Molecular y Medicina Genómica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Instituto de Investigaciones Biomédicas, UNAM

Uplifted marine terraces are an important tool for measuring neotectonic deformation, Quaternary sea levels, and other applications. Terraces have been mapped and studied worldwide, including along the Pacific coast of Baja California. To date, only limited terrace research has been done along the central Gulf coast of Baja, and even less work on the offshore islands of Bahía de Loreto, including Islas Carmen, Coronado, and Monserrat. We propose to map, precisely measure, and date these terraces to document paleo-sea level and quantify late Quaternary deformation and fault slip rates in the Loreto Basin. Based on reconnaissance fieldwork in 2018 and previously published studies, we hypothesize that the three closely spaced terraces on Isla Carmen include OIS 5a, 5c, and 5c, which would show uplift significantly more rapid than inferred on the Baja mainland and unusual preservation of sea-level variations through the last interglacial. We will sample and analyze terrace-capping littoral sediments and fossil assemblages on each level to assess paleo-environmental variations through the last interglacial period and back into the Pleistocene. We further hypothesize that Quaternary uplift and deformation in Bahía Loreto documents the transfer of faulting and tectonic deformation from the Baja mainland into the coastal margin and Gulf of California. This collaboration between UC Davis and UNAM and UABC is designed to catalyze further research and funded activity, including focused on a new UC Natural Reserve partner arrangement and potential field station in Loreto now being negotiated.

Nicholas Pinter, Earth and Planetary Sciences, UC Davis
John M. Fletcher, División de Ciencias de la Tierra, Centro de Investigación Científica y de Educación Superior de Ensenada

Variation in social structure is ubiquitous, yet we lack a comprehensive understanding of how these polymorphisms evolve and persist. Formica ants exhibit diverse social strategies, with variation in queen number and social parasitism. Here, we plan to develop a research infrastructure that will lead to rapid advances in our understanding of the causes and consequences of social variation while also laying the groundwork for ongoing research projects by our collaborative team. In particular, we will build upon a large dataset of Formica ants collected from California to Alaska by sampling toward the southern range limit of this genus in Mexico. Our objectives are: (1) Characterize the evolutionary history of a set of linked genes (= “supergene”) associated with queen number variation in Formica; (2) Identify and experimentally test ecological factors associated with social structure; (3) Seek patterns in the distribution of social parasite strategies and examine their impact on Formica social structure. To accomplish these goals, we will forge collaborations between ant experts from Riverside (Purcell lab, postdoc de la Mora), Los Angeles (postdoc Miller), Morelia (Janda lab), and Morelos (Valera lab) through data collection and analysis as well as shared mentoring, student exchange, and a collaborative methods training workshop.

Jessica Purcell, Entomology, UC Riverside
Fernando Varela Hernández, Professional Institute of the Southern Region (IPRES), Universidad Autónoma del Estado de Morelos

Conserving birds demands knowing whether populations can adapt to climate change. For migratory birds that inhabit multiple sites, it is uncertain whether beneficial adaptations at one site will be beneficial at another. A first step to resolving the uncertainty is establishing whether birds choose sites (e.g. breeding, wintering) with similar microclimates. Here, we test the hypothesis that birds that winter together all come from climatically similar breeding sites even if those sites are geographically distinct. We focus our study on the Yellow Warbler, a migratory songbird that breeds in the US and Canada and winters in the neotropics. We predict that genes associated with a particular microclimate in winter show the same relationship with microclimate on the breeding grounds. To identify gene-environment associations, we will sample the DNA of birds from different microclimates in Mexico’s Yucatan Peninsula and use an existing database to determine their breeding microclimates. We propose exchanges and workshops that will allow us to expand the study to other species and ask novel questions. The results of our study will inform UC Los Angeles projects related to bird genomics, migration, and climate change; help launch studies of bird genomics at CICY; and contribute to continental bird conservation initiatives.

Kristen Ruegg, Institute for the Environment and Sustainability, UC Los Angeles
Richard Feldman, Recursos Naturales, Centro de Investigación Científica de Yucatán

Atmospheric pollution is one of the major environmental challenges in Mexico and currently there is a shortage of professionals with knowledge in air quality modeling. The objective of this project is to contribute to the training of young researchers, university students and government technical personnel interested in air pollution, by providing them with the most advanced tools in air quality modeling and their applications, evaluation of strategies to control emissions and impacts on human health and the environment. Air quality models play an important role in atmospheric science due to their ability to assess the relative importance of the main physical and chemical processes that control air pollution. The models are also useful for quantifying the relationship between emissions, depositions (wet and dry), meteorology and concentrations, as well as for past and future scenarios, and the effectiveness of emission mitigation strategies. This makes the modeling of air quality an indispensable research tool in the design and evaluation of public policies based on emission control strategies. This in turn allows obtaining cost/benefit estimates of public policies and helping in the prioritization of their implementation. However, to connect all these parts in a highly reliable operating system, it is important to have highly trained and specialized personnel. Currently, there is a shortage of technical capacity in the academic and government sectors in Mexico for the development and application of modeling tools for the design and evaluation of air quality control strategies. There is also a strong need to increase the collaboration between these sectors and international experts to develop integrated research programs on the impacts of air pollution on human health, ecosystems and climate.

In this project, the researchers at the LTM Center for Energy and the Environment (LTMCE2) in Mexico and UC San Diego propose to develop and implement a symposium and a workshop in Mexico for intensive training in the modeling of air pollution and the evaluation of air quality control strategies using the regional air quality model Weather Research and Forecasting coupled with Chemistry (WRF-Chem). In addition to the co-principal investigators, US and Mexican experts in science and policy of air pollution will be invited as symposium speakers and training workshop instructors. The proposed workshop is directed to UC students and Mexican participants from academic/research institutions and government agencies. The results of this

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workshop will increase the technical capabilities in Mexico for the use of modeling tools in assessing pollution control strategies and the impacts of air pollution sources, as well as provide opportunities for UC students to collaborate with Mexican students, scientists and policy makers.

With the participation of researchers from UC San Diego, LTM Center, and other US and Mexican institutions, the symposium and workshop will serve as catalyst for developing basic and applied collaborative research, capacity building, and development of projects that apply research for air quality control. Furthermore, the workshop is expected to provide a platform for the subsequent projects for the development of modeling capabilities in air quality forecasting and evaluation of impacts on human health, ecosystems and climate. The interaction of Mexican and UC students will foster future research collaborations in air quality control. The project will also help to establish future collaborative initiatives between government agencies and academic/research institutions in developing research activities on air quality with the support of other institutional and extramural funds. In direct alignment with UC MEXUS-CONACYT program goals and objectives, the workshop will allow addressing the critical need of capacity building on air quality modeling in Mexico through the innovative and advanced training courses for public service technical officials, researchers, and student participants.

Lynn Russell, Climate, Atmospheric Science & Physical Oceanography at Scripps Institution of Oceanography, UC San Diego
Victor Almanza, Modelado, LTM Center for Energy and the Environment A.C.

In the current cosmological paradigm, structure grows hierarchically, making mergers an essential aspect of structure formation in the Universe. Galaxy mergers are frequently invoked as an important mechanism in several aspects of galaxy formation and evolution, from the triggering of luminous starbursts to the formation of galactic bulges and stellar halos. However, the frequency of galaxy mergers and their effects are rarely addressed in a robust, quantitative fashion for large samples of galaxies. This is now changing with the advent of large hydrodynamic cosmological simulations, which are able to produce reasonably realistic, yet statistically significant populations of galaxies in a full cosmological setting. We propose applying a robust merger tree construction code, along with a theoretical framework for studying stellar mass assembly, to cosmological hydrodynamic simulations from the IllustrisTNG Project, with the aim of investigating the frequency and effects of galaxy mergers in different environments. We will measure galaxy merger rates, accreted stellar mass fractions, density profiles of “in situ” and “ex situ” components, transition radii, and different measures of environment. Analyzing these data will advance our understanding of galaxy formation and evolution over an unprecedentedly wide range of environments, from isolated dwarf galaxies to massive galaxy clusters.

Laura Sales, Department of Physics & Astronomy, UC Riverside
Vicente Rodríguez-Gomez, Instituto de Radioastronomía y Astrofísica, UNAM

In this study we propose to reappraise the causal links between climate change, diet, and human mobility after the collapse of the Classic period Maya hegemonies. This research spans the Postclassic period (ca. 900-1500 CE) in Yucatan. Multiple lines of data suggest that this was a time of stress and increasing vulnerability for the Yukatec Maya speakers who populated this region in the centuries leading up to European contact. Through stable isotope (and osteological) analysis we propose to re-address this relationship through the lense of human remains, thus adding an innovative body-oriented perspective on how people responded to climate change and social disruption. Concretely, isotopic data of oxygen, strontium, carbon, and nitrogen from 75 individuals of 14 Postclassic Yucatecan Maya settlements is put in context with the corresponding (bio)archaeological information and regional baseline data. While the isotopic research itself will be conducted in U.S. facilities, contextual interpretation and osteological study will be undertaken south of the border. The multi-institutional exchange funded by this seed project will involve the participating research personnel and the students from UCR, UADY, ENAH, and UNAM, advance isotopic research on both sides of the border and strengthen the ties for future collaborations in innovative (bio) archaeology.

James Sickman, Environmental Sciences, UC Riverside
Vera Ingrid Gudrun Janine Tiesler, Facultad de Ciencias Antropológicas,
Universidad Autónoma de Yucatán

In finfish aquaculture, the use of immunostimulants has been recommended to improve fish performance and prevent fish disease induced by pathogens. Particularly, β Glucans are promising immunostimulants as benefic effects have been shown in several species. However, there have been contradictory results and more research should be done regarding the complexity of underlying mechanisms. Considering the great potential of Pacific white snook Centropomus viridis to intensive farming and the necessity to improve aquaculture protocols, we propose to investigate the protection conferred to C. viridis by β-Glucan in feed upon bacterial challenge; and investigate the immune response of C. viridis upon immunostimulation with β-Glucans in feed. As the transcriptome of C. viridis has recently been assembled, primers of relevant immune- related genes will be developed to determine expression levels by qPCR. In addition, histological samples and blood biochemical parameters of fish will be analyzed. The information obtained from this project will be published in a peer-reviewed journal and will also be presented by co-PIs and graduate student in scientific meetings, acknowledging the support of UC MEXUS and CONACYT.

Esteban Soto, Department of Medicine & Epidemiology, UC Davis
Francisco Neptalí Morales Serna, Unidad Mazatlán en Acuicultura y Manejo Ambiental,
Centro de Investigación en Alimentación y Desarrollo A.C.

Breast cancer is a major public health problem worldwide. Even though there are many therapeutic strategies available, the wide heterogeneity in, both tumor phenomenology and pharmacological response, as well as the prevailing phenomenon of drug resistance pose extraordinaire challenges to the clinical oncologist. In the last decades, during the postgenomic era new theoretical and technological tools are opening promissory ways to address these problems. Of particular interest here is the combination of the systems biology, translational bioinformatics and computational intelligence to combine personalized molecular and phenotypic profiling with information in extremely large databases of genomic, pharmacologic repositories. The usefulness of these results of the combined analyses should be evaluated in terms of drug repurposing in each breast cancer molecular subtype therapy. In favor of breast cancer patients, this methodology could be further developed to provide personalized treatment schemes. The latter are particularly needed in those breast cancer subtypes with limited therapeutic options or those who have developed resistance to the current pharmacological schemes.

Alejandro Sweet-Cordero, School of Medicine, UC San Francisco
Enrique Hernández-Lemus, Population Genomics, National Institute of Genomic Medicine (INMEGEN)

Was there an architectural template for Maya marketplaces during the Classic period (AD 250-900)? This binational project addresses this question through archaeological research at the Classic Maya city of El Palmar, located in southeastern Campeche. There is increasing evidence suggesting that market exchange was integral to ancient Mesoamerican societies. In the Maya lowlands attention has been drawn to the detection of physical marketplaces during the last decade. Scholars recognize an architectural configuration of long aligned buildings arranged in quadrangles, as the strongest archaeological correlate of marketplaces in the Maya lowlands. Despite this general recognition, activities within the buildings remain unknown.

This binational collaborative research will apply a multifaceted approach to examining the validity of marketplace templates in the Maya lowlands. Airborne LiDAR mapping around El Palmar detected an architectural complex, the Hernández Group, reminiscent of Calakmul’s Chiik Nahb complex and Tikal’s East Plaza which are prime examples of Classic Maya marketplaces. This project will combine geophysical prospections, auger probes, geochemistry, excavations, and artifactual analyses to yield a variety of empirical data associated with the possible archetype of Classic Maya marketplaces. This project will promote intellectual and cultural exchanges between scholars and students.

Kenichiro Tsukamoto, Anthropology, UC Riverside
Luis Barba, Instituto de Investigaciones Antropológicas, UNAM

Previous studies have documented barriers to healthcare access and low utilization of health services among Mexican immigrants in the U.S. Some of these barriers are low socio- economic status, language proficiency, lack of transportation and citizenship status. While funding for Federally Qualified Health Center’s (FHQCs) has been extended, their financial sustainability remains uncertain. Undocumented Mexican immigrants may be discouraged from using health providers such as FQHCs fearing deportation, especially due to recent changes to immigration enforcement policies. Additionally, documented immigrants eligible to Medicaid continue to face waiting periods. Moreover, recently proposed modifications to the definition of “public charge” could prevent them from benefiting from locally funding programs or discourage their use. The purpose of this study is to assess the short-term impact of the anti-immigrant policies and rhetoric from the current administration on access to care barriers, among Mexican immigrants in Los Angeles. This will be achieved using a mixed-methods approach, with data collected through face-to-face surveys and interviews among Mexican immigrants in the Mexican Consulate of Los Angeles. Results from this study will shed light on novel pathways through which immigrants may be affected by current policies, which could guide local and state governments in addressing these challenges.

Arturo Vargas-Bustamante, Health Policy and Management, UC Los Angeles
Mireya Vilar-Compte, Research Institute for Equitable Development (EQUIDE),
Universidad Iberoamericana

Nowadays, there is a growing concern about energy consumption and specifically on electricity consumption. This is the result of a continuous increase of the amount or energy required to maintain current wellbeing with unmatched production levels, creating an unsustainable situation. For this reason, the need of smarter energy utilization as a primary objective is required, being the electricity conversion one (maybe the best) example. In particular, the conversion of electricity into light is one of the most important uses (in terms of amount consumed), and currently the state-of-the-art in terms of efficiency are the solid-state lighting (SSL) devices derived from rare-earth elements. But this type of devices present important limitations: they are based on very scarce and expensive materials (the rare-earth elements), that in combination with the Asian-controlled supplies and the extension of environmental regulations, compromise their long-term viability. This project aims at the creation of efficient and stable SSL devices based on green-synthesized semiconductor polymers blended with quantum dots (QOLEDs) with promising electroluminescence performance. In this proposal a green chemistry approach (no transition metal catalysts, water as the only by-product) for preparation of pi-functional polymers will be explored to fabricate novel polymer architectures with tunable electronic properties.

Oscar Vázquez Mena, NanoEngineering, UC San Diego
José Antonio Ávila Niño, Eduardo de Jesús Coutiño González, and Lilian Iraís Olvera Garza, Electroquímica, Centro de Investigación y Desarrollo Tecnológico en Electroquímica (CIDETEQ)

Viruses are obligate intracellular parasites that have evolved for millions of years, capable of replicating in most, if not all, life forms. Humans possess an immunological system that allows them to counteract a large part of these invaders. Through coevolution between pathogen and host, however, viruses have developed different strategies to evade the immune response while the immune system adapts to those changes as a counteraction. These viral immune system evasion strategies are diverse and in most cases, involve structural and non- structural viral proteins. Harnessing host-pathogen co-evolution, the project pretends to evaluate the effect of viral proteins from some pathogens like the hepatitis C virus (HCV) on the activation, polarization and effector functions of four populations of human T lymphocytes, cells fundamental for the immune response. In this way, we intend to take advantage of the viral strategies to establish themselves and stay in their hosts, to manipulate in several scenarios the cellular protagonists of this defense system.

Armando Villalta, Physiology and Biophysics and the Institute for Immunology, UC Irvine
Marco A. De León Nava, Departamento de Innovación Biomédica, DBEA,
Centro de Investigación Científica y de Educación Superior de Ensenada (CICESE)

The Coastwide Olympia Oyster Network includes collaborators engaged in rigorous research and science-based restoration of the native Olympia oyster from British Columbia to Baja California. The Baja Peninsula is the southern limit of the oyster native to this coast, and supports a thriving aquaculture industry built on an introduced oyster species. Little is known about the ecology, distribution and population status of oysters in this region. Therefore, our objectives are: 1) to enhance fundamental research on oysters in Mexico by drawing on the expertise of US and Canadian collaborators to conduct research and strategic planning yielding recommendations for monitoring and management, and 2) to incorporate relevant ecological data about southern populations of Olympia oysters, likely at the forefront of climate change impacts, into the coastwide network activities including the design of a coordinated set of experiments to be conducted at sites from Mexico to Canada. The proposed work will complement the proposed UC MEXUS-CONACYT postdoctoral research into climate effects on oyster and predator species in Baja California. A UC MEXUS-CONACYT Collaborative Grant would provide critical seed funding to build a sustained international collaboration of marine conservation scientists who are committed to building on this effort in years to come.

Kerstin Wasson, Ecology and Evolutionary Biology, UC Santa Cruz
Julio Lorda Solórzano, Facultad de Ciencias, Universidad Autónoma de Baja California

Mexico and the United States of America are two of the largest producers of lemons and limes in the world. However, biotic and abiotic factors, as well as undesirable agronomic traits limit the production. In this work I propose to develop a high-quality genome assembly in order to support the genetic improvement of lemons and limes. This includes sequencing, assembly and annotation of the genome of Limoneira 8A lemon, identification of genetic changes that distinguish lemon and lime varieties, which are mainly originated by somatic mutations. The potential to identify candidate mutations causing interesting phenotypes using DNA sequencing technologies is a mayor outcome of this proposal. Moreover, these candidates will form the basis of future genome editing in lemons and limes.

Emmanuel Ávila de Dios, Ingeniería Genética, Centro de Investigación de Estudios Avanzados del Instituto Politécnico Nacional, Irapuato

The research expounded in this proposal aims to develop Metal-Organic Cages (MOCs), able to operate in water for molecular binding and catalysis, to be used as building blocks for constructing more intricate Metal-Organic Frameworks (MOFs). The integration of these two types of materials will allow taking advantage of the virtues of both classes of systems and overcoming many of their limitations; likewise, the use of MOCs as building blocks will afford the controlled programming of functions from cages to frameworks.

While The Yaghi Group is internationally renowned in supramolecular chemistry, boasting world-class expertise in construction of metal-organic reticular MOF systems and materials engineering, The Guzmán-Percástegui lab is a young research group working in the design of water-soluble porous cages. Although both groups share their interest in the design of functional metal-organic supramolecular materials that may impact human lives, the parties involved have never collaborated; thus, this application represents an excellent opportunity to do so and to establish a long-term US-Mexico collaboration on an important research area

Omar Yaghi, College of Chemistry, Department of Chemistry, UC Berkeley Edmundo Guzmán Percástegui, Instituto de Química, UNAM

This proposal aims at developing highly stable, efficient, and color-tunable metal halide perovskite quantum dots (PQDs) or nanocrystals (PNCs) for emerging light emitting diode (LED) applications. The focus is to enhance the stability and light emission efficiency of PQDs by surface passivation to reduce surface defects using metal oxides such as SiO2 or Al2O3 and polymers (PVP and PLA) while, at the same time, to use other metal ions as dopants (Mn2+, Al3+, Bi3+, and Cu+/2+) to dope or co-dope the PQDs to tune their electronic energy levels and thereby color of emitted light for ultimate white light emission applications. Both bulk and nanostructured metal halide perovskites, including PQDs or PNCs, show outstanding optoelectronic properties promising for photovoltaic (PV) and LED applications. These include both all inorganic (e.g. CsPbX3, X=I, Br, Cl)) and organic/inorganic hybrid (CH3NH3PbX3) perovskites that exhibit desired properties such as high charge carrier mobility, small exciton binding energy, large absorption coefficients, and long exciton diffusion lengths. However, instability of perovskites towards factors such as water and oxygen/light has limited their applications to date. We propose to use surface chemistry methods to enhance their stability, based on preliminary success we have achieved recently. For LED applications, both the light emission efficiency and color tunability need to be improved as well. The surface passivation strategy is expected to lead to enhanced light emission efficiency by reducing surface defect states, while color tunability will be addressed by doping with other metal ions. In addition, we propose to replace the lead component in the perovskite by bismuth (Bi3+) since Bi is more environmentally friendly and produced in large scale in Mexico (second place in production). Our recently discovered violet emission (420 nm) from Al3+ doping is highly desired as it can be used to generate any visible color by simple down conversion. We will compare different synthesis and device fabrication methods to study how the LED performance depends on the various materials parameters including size, shape, surface properties, doping, and film morphology. The key outcome of this project will be highly stable, efficient and color-tunable PQDs for LED applications in addition to a better fundamental understanding of their optical and electronic properties.

Jin Z Zhang, Biomolecular Science & Engineering, UC Santa Cruz
Tzarara López Luke, Ceramicos y Refractarios, UMSNH,
Instituto de Investigaciones en Metalurgia y Materiales

The extreme chemical complexity and variability of atmospheric organic aerosols (OA) have hindered a coherent understanding of their composition, origins, and formation mechanisms, which are key to unraveling their impacts on air quality, human health, and climate. Urban areas are usually large sources of volatile organic compounds (VOC) and OA. Metropolitan area of Mexico City is considered one of the largest urban areas in the world with approximately 24 million inhabitants. Despite that the general air quality has largely improved in Mexico City in terms of atmospheric criteria pollutants, little is known related to organic chemical composition and their role on air quality. In the proposed research, ambient primary and secondary OA chemical composition at a receptor site in Mexico City will be characterized comprehensively by coupling two novel mass spectrometry techniques on the molecular level. Through the analysis, we will be able to provide unprecedented details on the constituents and transformation processes of major atmospheric organic species at different seasons and times of day. The results of this project will also allow an improvement in understanding the role of various organic composition in Mexico City air quality.

Haofei Zhang, Department of Chemistry, UC Riverside
Omar Amador-Muñoz, Ciencias Ambientales, UNAM